Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
If you've been searching for a solution to problem drinking, you've likely come across The Sinclair Method (TSM). Unlike traditional recovery approaches that focus on abstinence, TSM helps people gradually reduce their alcohol consumption with the aid of Naltrexone—a prescription medication that blocks the brain’s reward response to alcohol.